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Autologous Exosomes From Platelet-rich Plasma as a Modern Tool of Regenerative Dentistry
Sponsor: Wroclaw Medical University
Summary
The aim of the research is the laboratory assessment of the content as well as the regenerative and anti-inflammatory potential of autologous exosomes (EXO) from platelet-rich plasma, as well as their comparison with other autologous products used in intra-articular injections (PRP, PRF). The material for the research will be obtained from patients of the Temporomandibular Joint Dysfunction Clinic at the University Dental Center in Wrocław with chronic pain of the temporomandibular joints and/or masticatory muscles and/or chronic disturbances in temporomandibular joint mobility, as well as from healthy individuals. In the subsequent stages, the biological material will be analyzed under laboratory conditions to compare the composition and biological properties of PRF, PRF and EXO.
Official title: Autologous Exosomes From Platelet-rich Plasma as a Modern Tool of Regenerative Medicine - Assessment of Content and Therapeutic Potential in the Process of Temporomandibular Joint Regeneration
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
68
Start Date
2026-04
Completion Date
2027-12
Last Updated
2026-04-06
Healthy Volunteers
Yes
Interventions
Laboratory analysis of the content and biological activity of PRP, PRF, and exosomes obtained from blood samples
Laboratory analysis include in vitro tests aimed to: (1) evaluation of the size and concentration of exosomes, (2) the measurement of the level of cytokines and growth factors in the samples of PRP, PRF and EXO, (3) comparison of the impact of exosomes, PRF and PRP (from the study and control groups) on the proliferation and migration of human chondrocytes and fibroblasts.
Locations (1)
Wroclaw Medical Uniwesity, Wroclaw
Wroclaw, Poland