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LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution Study
Sponsor: Hamad General Hospital
Summary
This prospective, non-randomized, unblinded pilot study evaluates and compares the intrapulmonary distribution of exogenous surfactant in preterm neonates when administered via Less Invasive Surfactant Administration (LISA) versus conventional endotracheal intubation (ETT). Lung ultrasound (LUS) will be utilized to assess the pioneer Surfactant Distribution Homogeneity Index (SDHI) to quantify the evenness and extent of surfactant-induced lung aeration. Secondary objectives include evaluating changes in LUS scores, short-term clinical respiratory outcomes, and feasibility parameters for guiding future larger-scale trials.
Official title: A Prospective Pilot Controlled Trial Comparing the Intrapulmonary Distribution of Exogenous Surfactant Between (LISA) and Conventional Endotracheal Intubation in Preterm Neonates With RDS Using Lung Ultrasound and the NOVEL Surfactant Distribution Homogeneity Index (SDHI)
Key Details
Gender
All
Age Range
24 Weeks - 42 Weeks
Study Type
INTERVENTIONAL
Enrollment
22
Start Date
2026-01-01
Completion Date
2026-07-30
Last Updated
2026-04-07
Healthy Volunteers
No
Conditions
Interventions
surfactant administration by ETT
Administration of exogenous surfactant (Beractant, 100 mg/kg in 4 mL/kg) via an endotracheal tube following intubation, accompanied by brief mechanical ventilation and extubation if feasible.
surfactant administration by thin catheter
Administration of exogenous surfactant (Beractant, 100 mg/kg in 4 mL/kg) via a thin catheter while the infant is maintained on non-invasive respiratory support (CPAP or NIPPV).
Locations (1)
Women's Wellness and Research Center (WWRC), Hamad Medical Corporation
Doha, Qatar