Clinical Research Directory

Association Between Vitamin D Level and Host Immune Response in Active Pulmonary Tuberculosis Patients With Chronic Pulmonary Aspergillosis

Sponsor: Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan

Summary

The goal of the study is to determine whether vitamin D levels are associated with cytokine profiles in patients with pulmonary tuberculosis, including those with chronic pulmonary aspergillosis. The main questions it aims to answer are: Is there an association between serum 25-hydroxyvitamin D levels and pro- and anti-inflammatory cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α) in patients with active pulmonary tuberculosis? Does this association differ in patients with pulmonary tuberculosis complicated by chronic pulmonary aspergillosis compared to those without CPA and to healthy individuals? Researchers will compare: Active pulmonary tuberculosis (PTB) patients PTB patients with chronic pulmonary aspergillosis (PTB-CPA) Healthy control subjects to see if differences in vitamin D levels are associated with variations in cytokine responses among these groups. Participants will: Provide blood samples for measurement of serum 25-hydroxyvitamin D Undergo laboratory assessment of cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α) using ELISA Be classified into study groups based on clinical diagnosis (PTB, PTB-CPA, or healthy controls)

Official title: Immunological and Epidemiological Features of the Influence of Concomitant Infections on the Course and Outcome of Chronic Respiratory Diseases

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