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Serial ctDNA and Molecular Residual Disease Monitoring in Neuroblastoma
Sponsor: Sun Yat-sen University
Summary
This prospective observational study evaluates serial circulating tumor DNA (ctDNA) and molecular residual disease (MRD) monitoring in patients with neuroblastoma. The study aims to characterize baseline genomic alterations, assess ctDNA detectability and dynamic changes during treatment and follow-up, compare tumor-informed personalized MRD assays with fixed-panel assays, and determine the clinical utility of ctDNA/MRD for treatment response assessment, molecular remission evaluation, relapse surveillance, and early detection of disease progression.
Official title: A Prospective Observational Study of Serial Circulating Tumor DNA and Molecular Residual Disease Monitoring for Molecular Profiling, Treatment Response Assessment, and Early Relapse Detection in Patients With Neuroblastoma
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2022-01-01
Completion Date
2026-12-31
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Locations (1)
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China