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NCT07516678

Serial ctDNA and Molecular Residual Disease Monitoring in Neuroblastoma

Sponsor: Sun Yat-sen University

View on ClinicalTrials.gov

Summary

This prospective observational study evaluates serial circulating tumor DNA (ctDNA) and molecular residual disease (MRD) monitoring in patients with neuroblastoma. The study aims to characterize baseline genomic alterations, assess ctDNA detectability and dynamic changes during treatment and follow-up, compare tumor-informed personalized MRD assays with fixed-panel assays, and determine the clinical utility of ctDNA/MRD for treatment response assessment, molecular remission evaluation, relapse surveillance, and early detection of disease progression.

Official title: A Prospective Observational Study of Serial Circulating Tumor DNA and Molecular Residual Disease Monitoring for Molecular Profiling, Treatment Response Assessment, and Early Relapse Detection in Patients With Neuroblastoma

Key Details

Gender

All

Age Range

Any - Any

Study Type

OBSERVATIONAL

Enrollment

200

Start Date

2022-01-01

Completion Date

2026-12-31

Last Updated

2026-04-08

Healthy Volunteers

No

Conditions

Locations (1)

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China