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Effects of Transcranial Temporal Interference Stimulation on Cognitive Function in Mild Cognitive Impairment
Sponsor: Shanghai University of Sport
Summary
To explore the effects of transcranial temporal interference stimulation (tTIS) on cognitive function and dual-task walking performance, as well as its underlying neuroimaging mechanisms, in individuals with mild cognitive impairment.
Official title: The Effects of Transcranial Temporal Interferential Electrical Stimulation on Cognitive Function, Dual-Task Performance and Neuroplasticity in Individuals With Mild Cognitive Impairment
Key Details
Gender
All
Age Range
60 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-04-15
Completion Date
2026-08-15
Last Updated
2026-04-09
Healthy Volunteers
No
Conditions
Interventions
Active Temporal Interference Stimulation (TIS)
Active tTIS delivered via surface electrodes targeting the hippocampus. Parameters: 2 mA baseline-to-peak intensity, 20-minute duration with 30-second ramp-up and ramp-down. The stimulation protocol is individualized based on each participant's T1-weighted structural MRI using finite element modeling to optimize electric field distribution to the hippocampal target.
Placebo / Sham TIS
Sham stimulation delivered using the same electrode placement and parameters as active stimulation. To mimic the sensory experience without effective neuromodulation, active current is delivered only during the 30-second ramp-up and ramp-down periods. During the 20-minute stimulation period, no current is delivered. Participants are unable to distinguish sham from active stimulation based on sensation.
Locations (1)
Shanghai University of Sport
Shanghai, Shanghai Municipality, China