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Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables
Sponsor: Friedrich-Alexander-Universität Erlangen-Nürnberg
Summary
The goal of this study is to learn about the effects of sacral neuromodulation in pediatric patients with gastrointestinal motility disorders. By combining advanced neuroimaging, patient-specific biophysical modeling, electrophysiological characterization, and clinical translation, the SMART-GUT project establishes a comprehensive framework to systematically investigate neuromodulation in this pediatric population. This integrative approach enables a direct link between mechanism, targeting, and clinical outcome.
Official title: Stimulation Modeling and Adaptive Response Tracking in Pediatric Gastrointestinal Motility Disorders
Key Details
Gender
All
Age Range
3 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2018-07-01
Completion Date
2029-12-31
Last Updated
2026-04-09
Healthy Volunteers
No
Conditions
Interventions
SNM/MRI/EMG
Participants are receiving clinical baseline evaluation, preoperative sacral and functional MRI, reconstruction of digital twin, surgical implantation of sacral neuromodulation including intraoperative testing, postoperative sacral and functional MRI, and clinical follow-up
Locations (1)
Pediatric Surgery in the Children's Hospital
Erlangen, Germany