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Evaluating The Use of CGF Made Gel in Mandibular Extraction Sites of Lower Impacted 3rd Molars.
Sponsor: Cairo University
Summary
The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) Gel help improve bone healing and reduce pain after the surgical removal of impacted lower third molars. The study aims to answer the following: Does packing CGF Gel into the extraction site improve bone density? Does the use of CGF Gel reduce postoperative pain for the patient? Researchers will evaluate the healing outcomes of patients receiving this treatment in a prospective case series study. Because this is a case series, all participants will receive the CGF Gel intervention rather than being compared to a placebo group. Participants in this study will: Undergo a blood draw to create the autologous CGF Gel from their own growth factors. Undergo the surgical extraction of an impacted lower third molar under local anesthesia. Have a CGF Gel placed in the extraction socket immediately following the tooth removal. Report their pain levels using a numeric scale on Day 1, Day 3, and Day 7 after surgery. Return for a follow-up CBCT scan three months after the procedure to evaluate bone density changes.
Official title: Clinical and Radiographic Evaluation of The Use of CGF Gel Packed in Fresh Odontectomy Site of Impacted Lower 3rd Molars (A Case Series Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-05-01
Completion Date
2026-12-30
Last Updated
2026-04-09
Healthy Volunteers
Yes
Conditions
Interventions
Concentrated Growth Factor (CGF) Gel
This is a third-generation autologous blood concentrate prepared using a dedicated centrifugation system. The process creates a fibrin-rich organic matrix from the patient's own blood, which is then packed into the fresh extraction socket to enhance healing.