Clinical Research Directory

Inclusion Criteria: * English-speaking (able to provide consent and complete questionnaires) * Citizen or holding permanent resident status * History of refractory epilepsy with intractable seizures and/or cognitive decline Exclusion Criteria: * Any current or past history of neurological disorders or acquired neurological disease other than epilepsy (e.g. stroke, traumatic brain injury), including intracranial lesions * Current history of poorly controlled headaches including intractable or poorly controlled migraines * Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.) * Possible pregnancy or plan to become pregnant in the next 6 months * Any metal in the head * Any metal in the body * Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator) unless otherwise approved by the responsible MD * Dental implants * Permanent retainers * Claustrophobia (a fear of small or closed places) * Back problems that would prevent lying flat for several hours * Regular night-shift work (second or third shift)