Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
ACTIVE NOT RECRUITING
NCT07521566
NA

Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Different Methods

Sponsor: Dokuz Eylul University

View on ClinicalTrials.gov

Summary

This randomized controlled clinical study aimed to evaluate the effectiveness of two different de-epithelialization techniques-extraoral scalpel and intraoral radiofrequency (RF)-used in the preparation of de-epithelialized connective tissue grafts (De-CTG) for the treatment of gingival recession. A total of 48 patients were randomly assigned into two groups, and all grafts were applied in combination with coronally advanced flap (CAF) surgery. Clinical and histological outcomes, including epithelial remnants, root coverage, keratinized tissue gain, surgical duration, and postoperative patient comfort, were assessed. The study seeks to identify a reliable, operator-independent method that minimizes epithelial remnants and improves clinical outcomes and patient experience.

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

48

Start Date

2025-09-19

Completion Date

2026-06

Last Updated

2026-04-13

Healthy Volunteers

Yes

Interventions

PROCEDURE

Extraoral de-epithelialization Group

Extraoral de-epithelialization of connective tissue grafts using a scalpel prior to graft placement.

PROCEDURE

Radiofrequency De-epithelialization

Intraoral de-epithelialization of connective tissue grafts using a radiofrequency device prior to graft placement.

Locations (1)

Dokuz Eylul University

Izmir, Turkey (Türkiye)