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Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Different Methods
Sponsor: Dokuz Eylul University
Summary
This randomized controlled clinical study aimed to evaluate the effectiveness of two different de-epithelialization techniques-extraoral scalpel and intraoral radiofrequency (RF)-used in the preparation of de-epithelialized connective tissue grafts (De-CTG) for the treatment of gingival recession. A total of 48 patients were randomly assigned into two groups, and all grafts were applied in combination with coronally advanced flap (CAF) surgery. Clinical and histological outcomes, including epithelial remnants, root coverage, keratinized tissue gain, surgical duration, and postoperative patient comfort, were assessed. The study seeks to identify a reliable, operator-independent method that minimizes epithelial remnants and improves clinical outcomes and patient experience.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2025-09-19
Completion Date
2026-06
Last Updated
2026-04-13
Healthy Volunteers
Yes
Interventions
Extraoral de-epithelialization Group
Extraoral de-epithelialization of connective tissue grafts using a scalpel prior to graft placement.
Radiofrequency De-epithelialization
Intraoral de-epithelialization of connective tissue grafts using a radiofrequency device prior to graft placement.
Locations (1)
Dokuz Eylul University
Izmir, Turkey (Türkiye)