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Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
Sponsor: Szeged University
Summary
Men enrolled in the study are assigned to each APHRODITE group. Group 2,3,4 are treated with either gonadotropin preparations or clompihene-citrate (except group 4). The type of the treatment (gonadotropin vs clomiphene) is randomized. After treatment, hormonal measurements, spermiogram and DNA fragmentation tests are repeated, allowing for analysis of the outcome.
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2024-09-01
Completion Date
2026-12-01
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
recFSH
recFSH 3x150NE sc weekly for 12 weeks
HCG injection
hCG 2x5000NE sc weekly for 12 weeks
Clomiphene Citrate 50 mg
clompihene-citrate 50mg p.o. daily for 12 weeks
Locations (1)
Reproductive Medicine Centre, Department of Obstetrics and Gynecology, University of Szeged
Szeged, Hungary