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Effect of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery
Sponsor: Alexandria University
Summary
Dexmedetomidine is a selective a-2 adrenergic agonist that provides sedative and analgesic effects. Intranasal dexmedetomidine has a slower and gradual onset compared to intravenous injection , with low incidence of nasal discomfort. Dexmedetomidine was tested at various doses and modes of administration, as well as different types of surgery and co-anesthetic drugs, as a single injection or continuous infusion. The authors have not agreed on the ideal clinical dose. The hypothesis is that intranasal dexmedetomidine 3mcg /kg will decrease the incidence of emergence agitation after strabismus surgery than dexmedetomidine 2 mcg/kg
Official title: Effect of Two Different Doses of Intranasal Dexmedetomidine on the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery , A Randomized Clinical Trial
Key Details
Gender
All
Age Range
3 Years - 6 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2026-03-01
Completion Date
2026-12-01
Last Updated
2026-09-30
Healthy Volunteers
No
Conditions
Interventions
high dex group
patients will receive 3 mcg/kg intranasal dexmedetomidine 45minutes before surgery
low dex group
patients will receive 2 mcg/kg intranasal dexmedetomidine 45minutes before surgery
Locations (1)
Alexandria University
Alexandria, Egypt