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taVNS During Exercise and Recovery in Chronic Spinal Cord Injury
Sponsor: University of the Balearic Islands
Summary
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic cardiovascular regulation during exercise and recovery in individuals with chronic spinal cord injury (SCI). Participants undergo two experimental conditions (active taVNS and sham stimulation) in a randomized crossover design while performing a standardized exercise protocol. Heart rate variability (HRV) is used as a non-invasive biomarker to assess autonomic nervous system dynamics across different phases (baseline, exercise, and recovery). The aim is to characterize physiological responses to neuromodulation and explore whether taVNS modulates autonomic adaptability in this population. This is a mechanistic physiological study designed to improve the understanding of autonomic regulation in SCI and to explore potential biomarkers of response to neuromodulation.
Official title: Transcutaneous Auricular Vagus Nerve Stimulation Modulates Autonomic Dynamics During Exercise and Recovery in Chronic Spinal Cord Injury
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
35
Start Date
2024-10-31
Completion Date
2024-10-31
Last Updated
2026-04-13
Healthy Volunteers
No
Conditions
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation
Non-invasive electrical stimulation applied to the auricular branch of the vagus nerve using transcutaneous electrodes during the experimental protocol.
Sham Stimulation
Sham stimulation delivered with identical device setup but without effective activation of the vagus nerve.
Locations (1)
University of the Balearic Islands
Palma de Mallorca, Balearic Islands, Spain