Clinical Research Directory

Inclusion Criteria: * ≥18 TO ≤45 years of age, any sex. * Meet the dry eye diagnostic criteria of the DEWS international consensus, and show both of the following two conditions: OSDI score between 18 and 80; NIBUT (Non-invasive tear break-up time) \< 8 seconds * Best corrected visual acuity ≥ 0.5(10/20) (in each eye). * Intraocular pressure between 5 and 21 mmHg (in each eye). * Women of childbearing potential must agree to use safe contraception during the study. * Willingness/ability to return for all study visits and to follow instructions from the study investigator and their staff. * Voluntary participation and signing of the informed consent form approved by the Ethics Committee. Exclusion Criteria: * NEI corneal fluorescein staining score \> 5 (in either eye). * Wore contact lenses within the past 14 days and cannot commit to not wearing them during the study period (3 months) (in either eye). * Received refractive surgery (LASIK, SMILE) or other ocular surgery, or had ocular trauma within the past 12 months (in either eye). * Had acute allergic conjunctivitis, infection, or ocular surface inflammation within the past 3 months (in either eye). * Eyelid abnormalities that affect eyelid function, such as nystagmus, blepharospasm, ectropion, entropion, or severe trichiasis (in either eye). * Previously diagnosed with glaucoma and received medical or surgical treatment (in either eye). * Currently receiving other ophthalmic or systemic treatments that may affect the tear film. * Allergy to fluorescein sodium. * Have a serious health condition that may limit their ability to participate. * Pregnant, breastfeeding, or planning to become pregnant. * Diagnosed with neurological or psychiatric disorders (e.g., severe anxiety, depression, or severe sleep disorder). * Have difficulty with physical movement. * Previous experience with traditional exercise such as Baduanjin. * Previous experience with laughter exercise.