Clinical Research Directory
Browse clinical research sites, groups, and studies.
Perioperative Hyperoxia vs Normoxia Biomarker Trial
Sponsor: Istanbul University
Summary
This single-center randomized interventional study evaluated the biological effects of two perioperative oxygen strategies in adults undergoing elective laparoscopic lower abdominal surgery under standardized general anesthesia. Participants were assigned to receive either normoxia (FiO2 0.35) or hyperoxia (FiO2 0.80) after intubation and throughout the intraoperative period. The study assessed perioperative changes in circulating biomarkers related to pulmonary epithelial stress, endothelial glycocalyx injury, oxidative stress, and inflammation, together with blood gas and hemodynamic parameters. The study was completed before registration and is being registered retrospectively.
Official title: Effects of Perioperative Hyperoxia Versus Normoxia on Pulmonary, Endothelial, and Inflammatory Biomarkers in Elective Laparoscopic Lower Abdominal Surgery
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
76
Start Date
2017-07-01
Completion Date
2019-02-01
Last Updated
2026-04-13
Healthy Volunteers
No
Interventions
Perioperative Oxygen Strategy - Normoxia
Normoxia arm: FiO2 0.35 Intervention started immediately after intubation and maintained intraoperatively
Perioperative Oxygen Strategy-Hyperoxia
Hyperoxia arm: FiO2 0.80 Intervention started immediately after intubation and maintained intraoperatively
Locations (1)
Istanbul University, Istanbul Faculty of Medicine
Istanbul, Turkey (Türkiye)