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NOT YET RECRUITING
NCT07526402
NA

Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation in Healthy Individuals

Sponsor: Sinop University

View on ClinicalTrials.gov

Summary

This randomized, participant-blinded, sham-controlled crossover study aims to investigate the acute effects of different frequency applications of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic physiological responses in healthy adults. Participants will receive sham (0 Hz), 10 Hz, 25 Hz, 50 Hz, and 100 Hz taVNS in separate sessions with washout periods between visits. Heart rate variability, blood pressure, pulse rate, respiratory rate, and subjective discomfort will be assessed before and after each intervention session.

Official title: Investigation of the Acute Effects of Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation on Autonomic Physiological Responses in Healthy Individuals

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

36

Start Date

2026-05-01

Completion Date

2026-09-01

Last Updated

2026-04-16

Healthy Volunteers

Yes

Interventions

DEVICE

Sham taVNS

Sham stimulation is delivered under conditions similar to active taVNS without meaningful vagal stimulation.

DEVICE

taVNS 10 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 10 Hz.

DEVICE

taVNS 25 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 25 Hz.

DEVICE

taVNS 50 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 50 Hz.

DEVICE

taVNS 100 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 100 Hz.

Locations (1)

Artvin Coruh University, Artvin Vocational School, Disabled Care and Rehabilitation Laboratory

Artvin, Turkey (Türkiye)