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NOT YET RECRUITING
NCT07526545
NA

Urine Prostate Screening Integrated With MRI for Early Detection of Prostate Cancer, UPRISE Trial

Sponsor: University of Michigan Rogel Cancer Center

View on ClinicalTrials.gov

Summary

This clinical trial tests how well a urine prostate cancer screening test, My Prostate Score 2 (MPS2), integrated with magnetic resonance imaging (MRI) works for early detection of prostate cancer. MPS2 is an investigational urine-based test designed to help identify the likelihood of having aggressive prostate cancer. MPS2 testing works by measuring specific early detection biomarkers that include genetic information. This next-generation test aims to address a major challenge in prostate cancer care-detecting only the cancers that truly need treatment. Results may lead to paradigm shifts in early detection algorithms and reduce reliance on MRI and biopsy.

Official title: UPRISE (Urine Prostate Screening Integrated With MRI for Prostate Cancer Early Detection)

Key Details

Gender

MALE

Age Range

50 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

800

Start Date

2026-09-01

Completion Date

2030-03-01

Last Updated

2026-06-09

Healthy Volunteers

Yes

Interventions

PROCEDURE

Biopsy Procedure

Undergo biopsy

DEVICE

Diagnostic Procedure

Undergo MPS2 urine test

OTHER

Electronic Health Record Review

Ancillary studies

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

Locations (1)

University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, United States