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Urine Prostate Screening Integrated With MRI for Early Detection of Prostate Cancer, UPRISE Trial
Sponsor: University of Michigan Rogel Cancer Center
Summary
This clinical trial tests how well a urine prostate cancer screening test, My Prostate Score 2 (MPS2), integrated with magnetic resonance imaging (MRI) works for early detection of prostate cancer. MPS2 is an investigational urine-based test designed to help identify the likelihood of having aggressive prostate cancer. MPS2 testing works by measuring specific early detection biomarkers that include genetic information. This next-generation test aims to address a major challenge in prostate cancer care-detecting only the cancers that truly need treatment. Results may lead to paradigm shifts in early detection algorithms and reduce reliance on MRI and biopsy.
Official title: UPRISE (Urine Prostate Screening Integrated With MRI for Prostate Cancer Early Detection)
Key Details
Gender
MALE
Age Range
50 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
800
Start Date
2026-09-01
Completion Date
2030-03-01
Last Updated
2026-06-09
Healthy Volunteers
Yes
Conditions
Interventions
Biopsy Procedure
Undergo biopsy
Diagnostic Procedure
Undergo MPS2 urine test
Electronic Health Record Review
Ancillary studies
Magnetic Resonance Imaging
Undergo MRI
Locations (1)
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States