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The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis
Sponsor: Istanbul University
Summary
The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were: Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis? Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment? Researchers compared participants with severe periodontitis to healthy participants without periodontitis. Participants with severe periodontitis: * Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved * Had full-mouth gum examinations * Provided blood samples at the start of the study and again at 2 and 6 months after treatment Healthy participants: * Had gum examinations * Provided blood samples for comparison at the start of the study
Key Details
Gender
All
Age Range
19 Years - 36 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2006-07-01
Completion Date
2010-06-01
Last Updated
2026-04-13
Healthy Volunteers
Yes
Conditions
Interventions
Non-surgical periodontal treatment
Non-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment.
Locations (1)
Istanbul University, Faculty of Dentistry, Department of Periodontology
Istanbul, Turkey (Türkiye)