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Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.
Sponsor: University Hospital, Bordeaux
Summary
Boys with posterior urethral valves (PUV) are at increased risk of developing febrile urinary tract infections (fUTIs). As shown in the CIRCUP trial, circumcision plus antibiotic prophylaxis reduces the risk of FUTIs compared with antibiotic prophylaxis alone. This multicenter randomised controlled trial prospectively compares circumcision alone with circumcision plus antibiotic prophylaxis for the prevention of fUTIs in boys with PUV, enriched with external historical data from the CIRCUP trial)
Key Details
Gender
MALE
Age Range
1 Day - 31 Days
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2026-04-13
Completion Date
2032-04-13
Last Updated
2026-04-14
Healthy Volunteers
No
Conditions
Interventions
Antibiotics strategy
daily antibiotic prophylaxis up to two years
Circumcision
Circumcision performed at the time of valve resection
Locations (13)
CHU de Besançon
Besançon, France
CHU de Bordeaux
Bordeaux, France
CHU de Limoges
Limoges, France
APHM
Marseille, France
CHU de Montpellier
Montpellier, France
CHU de Nantes
Nantes, France
APHP Hôpital Armand Trousseau
Paris, France
APHP Hôpital Necker
Paris, France
APHP Hôpital Robert Debré
Paris, France
CHU de Reims
Reims, France
CHU de Rennes
Rennes, France
CHU de la Réunion
Saint-Denis, France
CHU de Toulouse
Toulouse, France