Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
NOT YET RECRUITING
NCT07527442
PHASE2

Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.

Sponsor: University Hospital, Bordeaux

View on ClinicalTrials.gov

Summary

Boys with posterior urethral valves (PUV) are at increased risk of developing febrile urinary tract infections (fUTIs). As shown in the CIRCUP trial, circumcision plus antibiotic prophylaxis reduces the risk of FUTIs compared with antibiotic prophylaxis alone. This multicenter randomised controlled trial prospectively compares circumcision alone with circumcision plus antibiotic prophylaxis for the prevention of fUTIs in boys with PUV, enriched with external historical data from the CIRCUP trial)

Key Details

Gender

MALE

Age Range

1 Day - 31 Days

Study Type

INTERVENTIONAL

Enrollment

72

Start Date

2026-04-13

Completion Date

2032-04-13

Last Updated

2026-04-14

Healthy Volunteers

No

Interventions

DRUG

Antibiotics strategy

daily antibiotic prophylaxis up to two years

PROCEDURE

Circumcision

Circumcision performed at the time of valve resection

Locations (13)

CHU de Besançon

Besançon, France

CHU de Bordeaux

Bordeaux, France

CHU de Limoges

Limoges, France

APHM

Marseille, France

CHU de Montpellier

Montpellier, France

CHU de Nantes

Nantes, France

APHP Hôpital Armand Trousseau

Paris, France

APHP Hôpital Necker

Paris, France

APHP Hôpital Robert Debré

Paris, France

CHU de Reims

Reims, France

CHU de Rennes

Rennes, France

CHU de la Réunion

Saint-Denis, France

CHU de Toulouse

Toulouse, France