Clinical Research Directory

Inclusion Criteria: 1. Age \>18 years; 2. Karnofsky Performance Status (KPS) \>60; 3. Expected to receive at least one cycle of immune checkpoint inhibitor therapy; 4. Expected survival \>6 months. Exclusion Criteria: 1. Prior treatment with immune checkpoint inhibitors; 2. Active autoimmune diseases (including systemic lupus erythematosus, inflammatory bowel disease, rheumatoid arthritis, myasthenia gravis, scleroderma, etc.); 3. Use of systemic immunosuppressive agents within 14 days prior to enrollment (prednisone \>10 mg/day or equivalent); 4. Inability to provide biological samples.