Clinical Research Directory

Inclusion Criteria: 1. Age between 1 and 18 years, gender unrestricted. 2. Patients with histopathologically confirmed rhabdomyosarcoma, Ewing sarcoma, malignant rhabdoid tumor, or non-rhabdomyosarcoma soft tissue sarcoma. 3. Previous receipt of at least one line of systemic anti-tumor therapy with subsequent disease progression. 4. Presence of measurable target lesions according to RECIST 1.1 criteria. 5. Sufficient biopsy tissue can be obtained from either metastatic or primary lesions. 6. ECOG performance status score of 0 to 1. 7. Expected overall survival ≥ 6 months. 8. Adequate bone marrow reserve: HB ≥ 90 g/L; ANC ≥ 1.5×10⁹/L; PLT ≥ 80×10⁹/L. 9. Adequate hepatic and renal function: total bilirubin ≤ 1.5 × upper limit of normal (ULN); ALT and AST ≤ 2.5 × ULN; serum creatinine ≤ ULN. 10. Voluntary participation in the study with signed written informed consent form (ICF), good compliance, and willingness to comply with follow-up procedures. Exclusion Criteria: 1. Patients with peripheral nervous system disorders caused by the disease, or a history of significant psychiatric or central nervous system disorders. 2. Patients with severe infection or active peptic ulcer requiring treatment. 3. Patients currently participating in other clinical trials or who have participated within the past 3 weeks. 4. Patients deemed ineligible by the investigator for any other reason.