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Elements of Adaptive Immunity in Epithelial Ovarian Cancer
Sponsor: Hellenic Cooperative Oncology Group
Summary
The study seeks to evaluate the presence and correlation with clinical outcome of several components of adaptive immunity (TILs, TLS, plasma cells and PD-L1 expression) in tumor specimens of patients with EOC treated with carboplatin/paclitaxel chemotherapy.
Official title: Prognostic Significance of Adaptive Immunity Cell Infiltrates in the Microenvironment of High-grade Serous Ovarian Cancer.
Key Details
Gender
FEMALE
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
687
Start Date
2023-04-01
Completion Date
2025-06-22
Last Updated
2026-04-14
Healthy Volunteers
No
Interventions
Assessment of elements of adaptive immunity in tumor biopsies
Tertiary lymphoid structures, Plasma cells, p53 and CD8+ T cells will be evaluated at tumor biopsies of patients with advanced ovarian cancer treated with chemotherapy.
Locations (1)
Hellenic Cooperative Oncology Group
Athens, Greece