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HBV Reactivation in Immunocompromised Patients (REANT STUDY)
Sponsor: Yaşar Bayındır, MD
Summary
Background/Objective: Comorbidities represent a critical risk factor in the prognosis of patients receiving immunosuppressive therapy. For patients with anti-HBc IgG positivity requiring Hepatitis B virus (HBV) prophylaxis, the long-term physiological impact of oral antivirals remains a concern. This study aims to prospectively monitor bone, renal, and metabolic dysfunctions associated with oral antiviral use and other systemic risk factors over a long-term period. Methods: The REANT Cohort is designed as a 4-year, multicenter prospective study. The cohort will consist of patients initiated on HBV prophylaxis due to immunosuppressive treatment. Participants will undergo regular longitudinal assessments to evaluate bone mineral density, renal filtration and tubular functions, and metabolic profiles. The interplay between antiviral therapy, baseline comorbidities, and long-term organ dysfunction will be analyzed. Conclusion: The findings from the REANT Cohort are expected to provide robust evidence regarding the safety of long-term HBV prophylaxis and assist in the development of monitoring guidelines for immunosuppressed patients with latent HBV infection.
Official title: Management and Monitoring of HBV Reactivation in Immunocompromised Patients in Turkey (REANT STUDY)
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
490
Start Date
2026-03-09
Completion Date
2029-12-31
Last Updated
2026-08-04
Healthy Volunteers
No
Conditions
Interventions
Antiviral
Patients who take all antivirals recommended in the guidelines will be evaluated in the same group.
Locations (16)
Cukurova University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Adana, Turkey (Türkiye)
Ankara Gazi University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Ankara, Turkey (Türkiye)
Bilkent City Hospital Department of Infectious Diseases and Clinical Microbiology
Ankara, Turkey (Türkiye)
Akdeniz University, Faculty of Medicine, Department of Infectious Diseases and Clinical Mİcrobiology
Antalya, Turkey (Türkiye)
Dicle University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Diyarbakır, Turkey (Türkiye)
Diyarbakir, Memorial Hospital Department of Infectious Diseases and Clinical Microbiology
Diyarbakır, Turkey (Türkiye)
Bolu Düzce University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Düzce, Turkey (Türkiye)
Gaziantep University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Gaziantep, Turkey (Türkiye)
Istanbul Haydarpaşa Numune Training and Research Hospital
Istanbul, Turkey (Türkiye)
Istanbul Sancaktepe Martyr Prof. Dr. İlhan Varank Training and Research Hospital
Istanbul, Turkey (Türkiye)
Ege University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Izmir, Turkey (Türkiye)
Kocaeli University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Kocaeli, Turkey (Türkiye)
Rize Recep Tayyip Erdogan University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Rize, Turkey (Türkiye)
Samsun Ondokuz Mayıs University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Samsun, Turkey (Türkiye)
Şanlıurfa Harran University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Sanliurfa, Turkey (Türkiye)
Sivas Cumhuriyet University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology
Sivas, Turkey (Türkiye)