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Probiotic and Synbiotic Supplements in Hemodialysis Patients
Sponsor: Mansoura University
Summary
This single-center randomized controlled trial evaluated the effects of natural probiotic and synbiotic supplementation on clinical and biochemical characteristics in adults with end-stage renal disease receiving maintenance hemodialysis at the Urology and Nephrology Center, Mansoura University, Egypt. Participants were randomized into three groups (control, probiotic, and synbiotic), with supplementation given for 6 months in the intervention groups. The study assessed changes in uremic toxins (including p-cresyl sulfate) as the primary outcome, and cardiovascular parameters, quality of life, and cognitive function as secondary outcomes. The trial aimed to determine whether modulation of gut microbiota with probiotics or synbiotics can improve outcomes in hemodialysis patients
Official title: Effects of Probiotic and Synbiotic Administration on the Clinical and Biochemical Characteristics of Hemodialysis Patients: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Months - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-03-01
Completion Date
2025-10-05
Last Updated
2026-04-15
Healthy Volunteers
No
Interventions
Natural Probiotic Supplement
Oral natural probiotic supplementation was administered in addition to standard maintenance hemodialysis care for 6 months.
Natural Synbiotic Supplement (Probiotic + Prebiotic Oat Fiber)
Oral synbiotic supplementation (natural probiotic plus prebiotic fiber \[oat\]) was administered in addition to standard maintenance hemodialysis care for 6 months.
Locations (1)
Urology and Nephrology Center (UNC), Mansoura University
Al Mansurah, Dakahlia Governorate, Egypt