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Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid
Sponsor: University of Montana
Summary
Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.
Key Details
Gender
All
Age Range
18 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-06-05
Completion Date
2027-02-28
Last Updated
2026-06-03
Healthy Volunteers
Yes
Conditions
Interventions
Cosmed QuarkSpiro Dosimeter-Controlled Nebulizer
Laboratory spirometry system equipped with a dosimeter-controlled nebulizer used to deliver standardized aerosolized citric acid during cough challenge testing.
DeVilbiss 45 Handheld Nebulizer
Commercial handheld nebulizer used to deliver aerosolized citric acid during cough challenge testing.
Locations (1)
University of Montana
Missoula, Montana, United States