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Intranasal Insulin to Prevent Intensive Care Unit Delirium
Sponsor: Radboud University Medical Center
Summary
This study aims to assess the feasibility, tolerability, and exploratory efficacy of intranasal insulin to prevent delirium in ICU patients aged ≥65 years after complex elective cardiac surgery with cardiopulmonary bypass
Official title: Intranasal Insulin for the Prevention of Delirium in ICU Patients Undergoing Elective Cardiac Surgery: a Randomized, Double-blind, Placebo-controlled Pilot Trial (INSPIRE)
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-04-30
Completion Date
2026-07-30
Last Updated
2026-08-03
Healthy Volunteers
No
Conditions
Interventions
Intranasal insulin-40U
Intranasal isophane insulin administered twice daily. Each administration consists of two sprays of 10 IU (0.1 ml) in alternating nostrils, totalling to 40 IU per day.
Intranasal sodium chloride 0.9%
Intranasal sodium chloride 0.9% administered twice daily. Each administration consists of two sprays of 0.1 ml in alternating nostrils, totalling to 0.4mL per day.
Locations (1)
Radboud University Medical Center
Nijmegen, Gelderland, Netherlands