Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes

RECRUITING

NCT07532629

Sponsor: Karolinska Institutet

Summary

This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization. Biological samples will be collected from both female and male partners, including semen, vaginal, and blood samples, to characterize microbial composition and metabolic profiles. The study aims to examine how these biological profiles are associated with reproductive outcomes such as fertilization, pregnancy, miscarriage, and live birth. Participants will be followed longitudinally, and reproductive and obstetric outcomes will be obtained through linkage with national health registers.

Official title: Microbiome and Metabolome Profiles in Couples Undergoing IVF and Their Association With Reproductive Outcomes in a Prospective Longitudinal Cohort Study

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

OBSERVATIONAL

Enrollment

1000

Start Date

2022-06-10

Completion Date

2029-03-01

Last Updated

2026-04-16

Healthy Volunteers

Yes

Conditions

Infertility Assisted Reproductive Technology Pregnancy Complications Pregnancy Loss, Early Metabolome Microbiome

Locations (3)

Reproduktionsmottagning Malmö, Skånes universitetssjukhus

Malmo, Sweden

Karolinska Universitetssjukhuset

Stockholm, Sweden

Reproduktionscenter, Akademiska sjukuhset

Uppsala, Sweden

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