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Impact of Platelet Concentration in PRP on TMJ Subluxation
Sponsor: IBB University
Summary
This study is about a treatment for a jaw condition called temporomandibular joint (TMJ) subluxation. In this condition, the jaw can move too far forward during mouth opening, which may cause repeated jaw locking and problems with normal function. The treatment being studied is platelet-rich plasma (PRP) injections. PRP is made from a person's own blood and may help improve joint stability and reduce symptoms. In this study, 40 adults with TMJ subluxation were randomly assigned to receive PRP with either a lower or higher platelet concentration. Each participant received 2 injections, given 2 weeks apart. The study measured jaw pain, how often locking happened, mouth opening, and joint clicking before treatment, after 6 months, and after 5 years. The goal of this study is to find out whether the amount of platelets in PRP changes how well this treatment works.
Official title: Effect of Platelet Concentration in Platelet-Rich Plasma on Prolotherapy Outcomes in Temporomandibular Joint Subluxation: A Double-Blinded Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2016-04-01
Completion Date
2017-07
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
Low Platelet Concentration PRP (L-PRP)
Intra-articular and pericapsular injection of platelet-rich plasma prepared with Low platelet concentration..
High Platelet Concentration PRP (L-PRP)
Intra-articular and pericapsular injection of platelet-rich plasma prepared with high platelet concentration.
Locations (1)
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University
Cairo, Egypt