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A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)
Sponsor: Eli Lilly and Company
Summary
The purpose of this study is to evaluate how well LY4005130 works in participants with severe alopecia areata (hair loss) when compared with placebo, and how well it's tolerated and what side effects may occur. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study drug will be administered intravenously (IV) (into a vein in the arm). The study will last approximately 48 weeks, including screening.
Official title: A Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Proof of Concept Study to Investigate Efficacy and Safety of LY4005130 in Adult Participants With Severe Alopecia Areata
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-04-14
Completion Date
2027-10-10
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
LY4005130
Administered IV
Placebo
Administered IV
Locations (29)
Center For Dermatology Clinical Research, Inc.
Fremont, California, United States
Northridge Clinical Trials
Northridge, California, United States
Cura Clinical Research - Santa Clarita - Kelly Johnson Parkway
Santa Clarita, California, United States
Health Clinical Research, LLC
Miami, Florida, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Revival Research Institute, LLC
Troy, Michigan, United States
Stracskin
Portsmouth, New Hampshire, United States
Texas Dermatology and Laser Specialists - San Antonio - South New Braunfels Avenue
San Antonio, Texas, United States
Jordan Valley Dermatology & Research Center
South Jordan, Utah, United States
Kelowna Health and Memory Centre
Kelowna, Canada
Ryan Clinical Research Inc.
Newmarket, Canada
Dar Clinical Research - Ottawa - Hunt Club Road
Ottawa, Canada
SIMa Recherche
Verdun, Canada
Beijing Friendship Hospital Affiliate of Capital University
Beijing, China
Huashan Hospital, Fudan University
Shanghai, China
Shanghai Skin Disease Hospital
Shanghai, China
Tianjin Medical University General Hospital
Tianjin, China
Erasmus Medisch Centrum
Rotterdam, Netherlands
Centrum Badan Klinicznych PI-House sp. z o.o.
Gdansk, Poland
Diamond Clinic
Krakow, Poland
Dermedic Jacek Zdybski
Ostrowiec Świętokrzyski, Poland
Centrum Medyczne Ginemedica
Wroclaw, Poland
Chung-Ang University Hospital
Seoul, Dongjak-gu, South Korea
Inha University Hospital
Incheon, South Korea
Jeonbuk National University Hospital
Jeonju, South Korea
Seoul National University Hospital
Seoul, South Korea
Kyung Hee University Hospital at Gangdong
Seoul, South Korea
Chelsea and Westminster Hospital NHS Foundation Trust
London, United Kingdom
Salford Royal Hospital
Salford, United Kingdom