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AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Sponsor: Novo Nordisk A/S
Summary
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and type 2 diabetes. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Official title: Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Type 2 Diabetes (AMAZE 2)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
630
Start Date
2026-04-13
Completion Date
2028-08-07
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
NNC0487-0111
NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Placebo (matched to NNC0487-0111)
Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Locations (73)
Univ of Alabama Birmingham
Birmingham, Alabama, United States
Headlands Research California, LLC
Escondido, California, United States
Torrance Clinical Research Institute, Inc.
Lomita, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Northeast Research Institute
Fleming Island, Florida, United States
Jacksonville Ctr Clin Res
Jacksonville, Florida, United States
Florida Institute for Clinical Research, LLC
Orlando, Florida, United States
Oviedo Medical Research, LLC
Oviedo, Florida, United States
International Diabetes Center
Minneapolis, Minnesota, United States
Southgate Medical Group, LLP
West Seneca, New York, United States
Spartanburg Medical Research
Spartanburg, South Carolina, United States
M3 Wake Research Chattanooga
Chattanooga, Tennessee, United States
UT Southwestern Medical Center - Lingvay
Dallas, Texas, United States
PlanIt Research, PLLC
Houston, Texas, United States
National Clin Res Inc.
Richmond, Virginia, United States
MICA- Medicina e Investigación Cardiometabólica
Manuel Alberti, Buenos Aires, Argentina
Kynet Recoleta
Buenos Aires, Argentina
Centro médico privado Cemaic
Córdoba, Argentina
CEDIR - Centro de diagnóstico y rehabilitación Santa Fe
Santa Fe, Argentina
Cline Research Center
Curitiba, Paraná, Brazil
PUCCAMP - Hospital e Maternidade Celso Pierro
Campinas, São Paulo, Brazil
CPCLIN - Centro de Pesquisas Clínicas
São Paulo, São Paulo, Brazil
Centro de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina da USP
São Paulo, São Paulo, Brazil
Opca bolnica Karlovac
Karlovac, Croatia
Specijalna Bolnica za medicinsku rehabilitaciju Krapinske Toplice_Endocrinology
Krapinske Toplice, Croatia
Specijalna bolnica Thalassotherapia
Opatija, Croatia
Poliklinika SLAVONIJA OSIJEK
Osijek, Croatia
Opca bolnica Pula
Pula, Croatia
Poliklinika za oftalmologiju optometriju i neurologiju Lux
Solin, Croatia
Opca bolnica Varazdin_Endocrinology
Varaždin, Croatia
Poliklinika Solmed
Zagreb, Croatia
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
Szeged, Csongrád-Csanád, Hungary
DRC Kft.
Balatonfüred, Hungary
Szent Margit Rendelőintézet Nonprofit Kft.
Budapest, Hungary
Semmelweis Egyetem
Budapest, Hungary
PVN Kutató Kft.
Budapest, Hungary
Észak-Pesti Centrumkórház Honvédkórház - Diabetológia Szakrendelés
Budapest, Hungary
Trantor 99 Bt
Budapest, Hungary
Somogy Vármegyei Kaposi Mór Oktató Kórház
Kaposvár, Hungary
Dip. Med. Chir. delle malattie digestive, epatiche ed endo-meta - UOC Endocrinologia e prevenzione e cura del diabete
Bologna, Emilia-Romagna, Italy
Universita Degli Studi Di Roma La Sapienza - Policlinico Umberto I Medicina Sperimentale
Rome, Lazio, Italy
Grande Ospedale Metropolitano Niguarda - Dipartimento Medico Polispecialistico - Diabetologia
Milan, Lombardy, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - PSD Nutrizione Clinica, Obesità e Metabolismo
Palermo, Sicily, Italy
IRCCS Ospedale San Raffaele Milano
Milan, Italy
Dip. di Medicina Interna Policlinico Universitario Palermo
Palermo, Italy
Centro de Investigacion Clinica Endocrinologica de Jalisco
Guadalajara, Jalisco, Mexico
Clinstile S.A. de C.V.
Col Roma Norte, Mexico City, Mexico
Instituto Nacional de Nutricion - Unidad de Inv de Enf Metab
Distrito Federal, México, D.F., Mexico
Unidad Medica para la Salud Integral (UMSI)
San Nicolás de los Garza, Nuevo León, Mexico
Centro de Investigación Clinica de Oaxaca (CICLO)
Oaxaca City, Oaxaca, Mexico
Consultorio de Endocrinología y Pediatría
Puebla City, Mexico
S.C. Top Diabet Srl
Craiova, Dolj, Romania
Poli Cardinal Med Srl
Reghin, Mureș County, Romania
CMI Dr. Pletea Noemi SRL
Bacau, Romania
SC Nutrilife SRL
Bucharest, Romania
SC Clinica Diabnutrimed S.R.L.
Bucharest, Romania
Diabet Med SRL
Bucharest, Romania
Cmi Dr. Cojocaru Cristina
Constanța, Romania
A&C Medical Prime S.R.L.
Craiova, Romania
Spital Judetean De Urgenta Satu Mare
Satu Mare, Romania
DIA - KONTROL s.r.o.
Levice, Slovakia
Narodny Endokrinologicky a diabetologicky ustav
Ľubochňa, Slovakia
OLIVER - MED s.r.o.
Rimavská Sobota, Slovakia
Peter Farkas MD, s.r.o.
Šahy, Slovakia
DEImedi, s. r. o.
Šurany, Slovakia
ARETEUS s.r.o.
Trebišov, Slovakia
Seoul National University Bundang Hospital_Endocrinology
Seoungnam-si, Gyeonggi-do, South Korea
Chonnam National University Hospital_Endocrinology
Gwangju, South Korea
Kyunghee University Medical Center_Endocrinology
Seoul, South Korea
Seoul National University Hospital_Endocrinology
Seoul, South Korea
Severance Hospital, Yonsei University Health System_Endocrinology
Seoul, South Korea
Asan Medical Center_Endocrinology
Seoul, South Korea
The Catholic University of Korea, Yeouido ST. Mary's Hospital_Endocrinology
Seoul, South Korea