Clinical Research Directory

Inclusion Criteria: 1. MOVIE-West Africa * Individuals of any sex and age. * Confirmed Mpox cases who tested positive for MPXV by PCR. * Symptom onset within the 10 days prior to the baseline assessment. * Willingness and ability to comply with study procedures and attend scheduled follow-up visits for up to two months. * Availability for follow-up throughout the study period. * Provision of written informed consent by the participant, or consent by a legally authorized representative for minors or individuals unable to provide it themselves. * Assent obtained from children aged 12 to 17 years. * For individuals who cannot read or write, witnessed consent will be obtained. 2. TRACE-West Africa * Individuals who have had close physical contact with a PCR-confirmed Mpox case within 14 days from the onset of symptoms in the index case. * Close physical contact is defined as being within 2 meters of an infected person-particularly in enclosed spaces-for at least 5 minutes (based on CDC's 2-meter rule for droplet transmission). * Willingness and ability to comply with the study protocol and attend scheduled follow-up assessments. * Provision of written informed consent by the participant, or consent by a legally authorized representative for individuals unable to provide it themselves. * Assent obtained from children aged 12 to 17 years. * For individuals who cannot read or write, witnessed consent will be obtained. 3. VE-West Africa * The inclusion criteria for Mpox cases in VE-West Africa are same as those in MOVIE-West Africa. * The inclusion criteria for contacts of Mpox cases in VE-West Africa are as follows. * Individuals who have had close physical contact with a PCR-confirmed Mpox case within 14 days from the onset of symptoms in the index case. * Close physical contact is defined as being within 2 meters of an infected person-particularly in enclosed spaces-for at least 5 minutes (based on CDC's 2-meter rule for droplet transmission). * Individuals living, working or studying in a community where mpox vaccination is being offered. * Willingness and ability to comply with the study protocol and attend scheduled follow-up assessments. * Provision of written informed consent by the participant, or consent by a legally authorized representative for individuals unable to provide it themselves. * Assent obtained from children aged 12 to 17 years. * For individuals who cannot read or write, witnessed consent will be obtained. Exclusion Criteria: (1) MOVIE-West Africa * Cases of severe Mpox requiring hospitalization. * Individuals with a confirmed alternative diagnosis explaining their illness. (3) VE-West Africa * The exclusion criteria for Mpox cases in VE-West Africa are as follows. * Cases of severe Mpox requiring hospitalization. * Individuals with a confirmed alternative diagnosis explaining their illness.