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NCT07534397

Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation

Sponsor: The University of Texas at Dallas

View on ClinicalTrials.gov

Summary

The purpose of this research study is to examine the effects of transcranial Direct Current Stimulation (tDCS) on verbal retrieval and cognition and sensorimotor control and to determine if tDCS can be used as a way to improve retrieval, sensory, and motor abilities in individuals with Parkinson's disease (PD).

Key Details

Gender

All

Age Range

50 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2026-05-01

Completion Date

2027-10-31

Last Updated

2026-04-16

Healthy Volunteers

Conditions

PARKINSON DISEASE (Disorder)

Interventions

DEVICE

transcranial direct current stimulation

Transcranial direct current stimulation will be delivered via a Neuroelectrics Starstim tES. Stimulation will consist of 1 milliamp stimulation, with anodal stimulation delivered at electrode Fz (International 10/10 System for electroencephalography electrode placement) and electrodes F7, FP1, FP2, and F8 as returns. All electrodes are 1 cm diameter Ag/AgCl electrodes and make contact with the scalp via connective gel. Stimulation will linearly ramp up from 0 milliamps to 1 milliamp over 60 seconds, then remain at 1 milliamp of stimulation over 20 minutes, and finally ramping down at to 0 milliamps over 60 seconds.

DEVICE

Sham transcranial direct current stimulation

Sham transcranial direct current stimulation will be delivered via a Neuroelectrics Starstim tES. The sham setup will consist of anodal electrode Fz (International 10/10 System for electroencephalography electrode placement) and electrodes F7, FP1, FP2, and F8 as returns. All electrodes are 1 cm diameter Ag/AgCl electrodes and make contact with the scalp via connective gel. Stimulation will linearly ramp up from 0 milliamps to 1 milliamp over 60 seconds, ramp down to 0 milliamps over 60 seconds and then be left off for 20 minutes.

Inclusion Criteria: * Diagnosed with PD having a verbal fluency deficit * 50 - 90 years old * Capable of understanding and signing an informed consent (able to answer consent comprehension questions) * Fluent in speaking and reading English Exclusion Criteria: * A potentially confounding psychological or neurological disorder, including, epilepsy or other seizure disorders; severe traumatic brain injury (based on the Ohio State TBI Identification Method); brain tumor; stroke; present drug abuse/misuse; or Huntington's disease. Participants being seen in the PIs clinics will be assessed for these issues as a part of the standard clinical assessment. * Additionally, exclusion criteria include cranial implants or skull defects that affect tDCS administration; and use of medications that interact with or potentially interact with tDCS effects, including, anti-convulsants, carbamazepine, sulpiride, pergolide, lorazepam, rivastigmine, dextromethorphan, D-cycloserine, flunarizine, ropinirole, or citalopram * Patients with a diagnosis of just dysarthria or who have a deep brain stimulation (DBS) device will be excluded. * Additionally, non-English speakers will be excluded because not all of the screening forms, questionnaires, and tests are available in languages other than English. * Individuals with cognitive impairment, as indicated by a score of 22 or less on the Montreal Cognitive Assessment, will be considered for exclusion due the concern of a reduced ability to consent. Participants with a score of 22 or less will only be able to participate if they have an accompanying study partner/caregiver with them and we can obtain the written consent of both the participant and the participant's accompanying study partner/caregiver who will be the participant's spouse, adult child, parent, or adult sibling. If they do not have an accompanying study partner/caregiver, they will not be allowed to participate at that time. However, they will be allowed to come back at a later date with an accompanying study partner/caregiver and move forward with the consent procedures and study as above.

Clinical Research Directory

Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation

Summary

Key Details

Conditions

Interventions

Eligibility Criteria