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Mechanical Power Ventilation in RALP
Sponsor: Ankara City Hospital Bilkent
Summary
Robot-assisted laparoscopic radical prostatectomy (RALP) requires steep Trendelenburg positioning and pneumoperitoneum, which adversely affect respiratory mechanics and may lead to impaired postoperative oxygenation. Mechanical power (MP) has recently emerged as a comprehensive parameter reflecting the total energy delivered from the ventilator to the respiratory system and may be associated with ventilator-induced lung injury. This prospective randomized controlled trial aims to evaluate whether a mechanical power-targeted ventilation strategy improves postoperative oxygenation compared to standard ventilation in patients undergoing RALP. The primary outcome is the oxygenation index (OSI) at the postoperative second hour. Secondary outcomes include PaO₂/FiO₂ ratio, postoperative pulmonary complications, and length of hospital stay.
Official title: Mechanical Power-Targeted Ventilation in Robot-Assisted Laparoscopic Radical Prostatectomy: A Prospective Randomized Controlled Trial
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-04-15
Completion Date
2026-07-30
Last Updated
2026-04-16
Healthy Volunteers
Yes
Conditions
Interventions
Mechanical Power-Targeted Ventilation
Ventilation adjusted to achieve the lowest possible mechanical power (≤14 J/min) using titration of PEEP and respiratory rate.
Standard Ventilation
Conventional ventilation strategy with fixed PEEP (5 cmH₂O) and routine settings.
Locations (1)
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye)