Clinical Research Directory

Inclusion Criteria (Adults with IBM): * Diagnosis of Inclusion Body Myositis: As defined by the revised European Neuromuscular Centre 2013 diagnostic criteria (Definite or Probable IBM) * Age: Adults aged ≥40 years at the time of consent. * Ability to Provide Informed Consent: Participants must be cognitively capable of providing written, informed consent. * Disease Progression: Participants must be able to walk short distances, with or without the use of an assistive aid (e.g., a cane or frame) for balance, so that they can undertake study procedures without safety concerns. Must be able to consume solid or modified-texture food, with or without dysphagia adaptations (i.e., not exclusively tube-fed). * Willingness to Participate: Willing to attend study visits and comply with all study procedures. Inclusion Criteria (Control Participants): * Disease-Free: Control participants must be generally healthy, with no known myopathies or metabolic diseases. They must not have any conditions that, in the judgement of a clinician, would compromise their safety, impair their ability to complete study procedures, or influence study outcomes. * Age: Adults aged ≥40 years at the time of consent. * Ability to Provide Written Informed Consent * Willingness to Participate * Matched to IBM participants according to their age and physical activity levels Exclusion Criteria (Adults with IBM): * Coexisting Neuromuscular or Metabolic Disorders: Presence of other neuromuscular or metabolic disorders that may confound the outcomes of interest. * Severe Dysphagia: Participants requiring exclusive enteral or parenteral feeding, which would prevent participation in dietary intake assessments. * Enrolment in an interventional trial within the past 3 months: Participation in an interventional study within the past 3 months involving interventions that may affect dietary habits, physical activity, or muscle metabolism. * Contraindications to any Study Procedures: Any condition preventing safe completion of key assessments. For instance: severe osteoporosis contraindicating DXA scanning (T-score \< -3.0), respiratory conditions, severe claustrophobia, severe cognitive impairments or communication barriers that may impair participant ability to comply with study procedures. * Logistical Concerns: Any other logistical concern, as judged by the CI, that would compromise participant safety or the integrity of study data. * English Comprehension: Participants will be excluded if they are unable to understand written or verbal English to a degree that would impair their ability to provide informed consent or fully understand the study procedures. Exclusion Criteria (Control Participants): * Diagnosed neuromuscular or metabolic Disorder * Enrolment in an interventional trial within the past 3 months * Contraindications to any study procedures such as those listed for IBM participants (e.g., DXA, MRI). * Logistical or safety concerns, as judged by the research team. * To minimise dietary overlap, individuals living in the same household as an IBM participant will not be eligible. * Do not meet the physical activity criteria to be appropriately matched to an IBM participant * Unable to understand written or verbal English