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Antihistamine for Prevention of HTR After Blood Primed CPB
Sponsor: Kasr El Aini Hospital
Summary
This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.
Official title: Prophylactic Antihistamine for Prevention of Hypotensive Transfusion Reaction After Blood Primed Cardiopulmonary Bypass in Pediatric Cardiac Surgery: a Randomized-controlled Study
Key Details
Gender
All
Age Range
1 Year - 7 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-03-01
Completion Date
2026-12
Last Updated
2026-04-21
Healthy Volunteers
No
Interventions
Antihestamine
chlorpheniramine 0.25 mg/Kg in 2 ml immediately after separation from CPB, before protamine administration
Placebo
equal volume normal saline
Locations (1)
Misr Universty for Scince and Technology
Giza, October, Egypt