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Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke
Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Summary
The EXTEND-TNK Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous tenecteplase administered beyond 4.5 hours after last known well in patients with acute ischemic stroke (AIS) in routine clinical practice across China.
Official title: Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke (EXTEND-TNK Registry)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
3000
Start Date
2026-04
Completion Date
2029-12
Last Updated
2026-04-17
Healthy Volunteers
No
Conditions
Interventions
Tenecteplase
Intravenous tenecteplase 0.25 mg/kg (maximum 25 mg) administered as a single IV bolus over 5-10 seconds. In this observational cohort, tenecteplase is the only thrombolytic agent included and there is no active comparator.
Locations (2)
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Liuyang Jili Hospital
Guankou, Hunan, China