Clinical Research Directory

Inclusion Criteria: 1. Participant is at least 18 years of age and not older than 75 years of age 2. Participant is willing and able to provide written informed consent to participant in this study 3. Participant has symptoms of TMJ arthralgia (pain) with significant temporomandibular joint pain and dysfunction despite at least 30 days of conservative therapy (NSAIDS, muscle relaxants, bite splints, PT, warm compresses, soft diet, etc.) 4. Participant has baseline pain of ≥30 on a 100mm visual analog scale (VAS) Exclusion Criteria: 1. Participant has not competed at least 30 days of conservative therapy 2. Participant was diagnosed with central or neuropathic pain disorder 3. Participant has a primary diagnosis of myofascial pain 4. Participant has fibromyalgia 5. Participant is pregnant or breastfeeding 6. Participant had traumatic injury to the masticatory muscles or temporomandibular joint within 12 months of screening 7. Participant who has the following contraindications to MRI: * Electrical implants such as cardiac pacemakers or perfusion pumps * Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial heart, valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the eye, or steel implants * History of seizures * Patients with GFR \< 15 ml/min/1.73m2 or who are on dialysis will be excluded from the study. * Allergy to contrast die