Crisaborole vs Fluticasone Propionate in Mild to Moderate Atopic Dermatitis

COMPLETED

NCT07537751

NA

Sponsor: Noura Abdelmoneim Mohammed Elseessy

Summary

This randomized, double-blind trial compared topical crisaborole 2% with topical fluticasone propionate 0.05% in children aged 1-12 years with mild to moderate atopic dermatitis. Forty patients were assigned to receive either crisaborole or fluticasone twice daily on affected areas for 6 weeks, with responders (\>75% improvement in SCORAD) continuing the same treatment twice weekly for 12 weeks as maintenance. The study evaluated improvement in disease severity using SCORAD and ISGA, pruritus scores, disease-free survival, and local tolerability. Both treatments were effective and well tolerated; fluticasone produced faster short-term improvement, while crisaborole showed a trend toward fewer relapses and similar overall safety in this pediatric population.

Official title: Comparative Study Between Topical Crisaborole 2% and Topical Fluticasone Propionate 0.05% in Treatment of Patients With Mild to Moderate Atopic Dermatitis

Key Details

Gender

All

Age Range

1 Year - 12 Years

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2024-02-01

Completion Date

2025-03-01

Last Updated

2026-04-17

Healthy Volunteers

No

Conditions

Atopic Dermatitis Eczema

Interventions

DRUG

Crisaborole 2% topical ointment

Crisaborole 2% topical ointment applied in a thin layer to all affected atopic dermatitis lesions twice daily for 6 weeks, followed by twice-weekly application for 12 weeks as maintenance in patients who achieve more than 75% improvement in SCORAD at Week 6.

DRUG

Fluticasone propionate 0.05% topical cream

Fluticasone propionate 0.05% topical cream applied in a thin layer to all affected atopic dermatitis lesions twice daily for 6 weeks, followed by twice-weekly application for 12 weeks as maintenance in patients who achieve more than 75% improvement in SCORAD at Week 6.

Locations (1)

Faculty of Medicine, Kafr Elsheikh University

Kafr ash Shaykh, Kafr el-Sheikh Governorate, Egypt

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