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RECRUITING
NCT07537998
PHASE2/PHASE3

Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.

Sponsor: Pei-Rong Ding

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if antegrade intestinal fluid reinfusion works to prevent low anterior resection syndrome (LARS) in patients with prophylactic ileal stoma. The main questions it aims to answer are: 1. Does it work to prevent LARS by antegrade intestinal fluid reinfusion before performing the ileostomy reversal surgery? 2. Is antegrade intestinal fluid reinfusion more effective than water infusion in preventing LARS. Participants will: 1. Receive either antegrade intestinal fluid reinfusion or antegrade water infusion through ileal stoma based on the standard of care at 1 month after anterior rectal resection, until the ileostomy reversal. 2. Keep a diary of their symptoms.

Official title: Antegrade Intestinal Fluid Reinfusion Verse Water Infusion Through Prophylactic Ileal Stoma for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

160

Start Date

2026-04-10

Completion Date

2028-04-10

Last Updated

2026-04-17

Healthy Volunteers

No

Interventions

COMBINATION_PRODUCT

intestinal fluid infusion

Prepare autologous intestinal fluid and perform rantegrade reinfusion from the distal end of the stoma.

COMBINATION_PRODUCT

potable water

Infuse potable water through the distal end of the stoma.

Locations (1)

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China