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Caries Removal Methods and Microbiome Changes
Sponsor: Nuh Naci Yazgan University
Summary
Dental caries management approaches may influence not only tissue removal but also the microbial composition within the cavity. However, clinical evidence on how different caries removal methods affect the oral microbiome remains limited. This study aims to evaluate the effects of selective and non-selective caries removal methods on the diversity and composition of the oral microbiome using 16S rRNA gene sequencing. The findings are expected to help identify biologically compatible treatment approaches that effectively reduce pathogenic microorganisms.
Official title: Microbiome Changes in Cavities Prepared With Different Caries Removal Methods
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2026-02-26
Completion Date
2026-08
Last Updated
2026-04-20
Healthy Volunteers
Yes
Conditions
Interventions
Non-selective caries removal
Non-selective caries removal involves the complete excavation of infected dentin using conventional rotary instruments. Both infected and affected dentin are removed until hard dentin is reached, aiming to eliminate all carious tissue.
Selective caries removal
Selective caries removal involves complete caries removal at the cavity margins while preserving softened dentin near the pulp to reduce the risk of pulp exposure and maintain tooth vitality.
Locations (1)
Nuh Naci Yazgan University Faculty of Dentistry
Kayseri, Kocasinan, Turkey (Türkiye)