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Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Summary
INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.
Official title: Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension in High-Risk Non-Cardiac Surgery Patients - The Multicenter INDUCT Trial (INDUCT-Multi)
Key Details
Gender
All
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
446
Start Date
2026-05-07
Completion Date
2026-12
Last Updated
2026-05-13
Healthy Volunteers
No
Conditions
Interventions
Continuous Norepinephrine Administration
In patients assigned to continuous administration of norepinephrine, a syringe infusion pump will be prepared and connected to a peripheral or central venous catheter. The responsible anesthesiologist will start the norepinephrine infusion and adjust the infusion rate as necessary and may administer additional norepinephrine boluses via the syringe infusion pump if required.
Locations (4)
Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf
Düsseldorf, Germany
Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, University Hospital Giessen, Justus-Liebig University Giessen
Giessen, Germany
Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf
Hamburg, Germany
Department of Anaesthesiology, University Hospital LMU Munich
München, Germany