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Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth
Sponsor: Cairo University
Summary
This study aims to clinically and radiographically evaluate the effect of Concentrated Growth Factors (CGF) on the outcomes of autotransplantation of closed apex teeth. Tooth autotransplantation is considered a viable treatment option for replacing missing teeth; however, its success may be influenced by factors such as periodontal healing and pulpal revascularization, especially in teeth with closed apices. Concentrated Growth Factors (CGF), as an advanced generation of platelet concentrates, are rich in growth factors that may enhance tissue regeneration, promote healing, and improve the success rate of transplanted teeth. In this study, patients requiring tooth autotransplantation will be treated using CGF at the recipient site. Clinical outcomes, including tooth stability, periodontal health, and presence of complications, will be assessed. Radiographic evaluation will be performed to monitor bone healing, root resorption, and periodontal ligament integrity over a defined follow-up period. The findings of this study are expected to provide evidence regarding the potential benefits of CGF in improving the success and prognosis of autotransplanted closed apex teeth.
Official title: Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth (A Case Series Study).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
7
Start Date
2026-06
Completion Date
2027-07
Last Updated
2026-05-07
Healthy Volunteers
No
Conditions
Interventions
closed apex teeth auto transplantation
In this study, autotransplantation of teeth with closed apices will be performed following standard surgical protocols. The donor tooth will be atraumatically extracted with maximum preservation of the periodontal ligament, and the recipient socket will be carefully prepared to receive the transplanted tooth. In the intervention group, Concentrated Growth Factors (CGF) will be prepared from the patient's venous blood using a standardized centrifugation protocol. The obtained CGF will be applied to the recipient socket prior to placement of the donor tooth to enhance healing and promote tissue regeneration.
Locations (1)
Faculty of oral and dental surgery cairo university
Cairo, Elmanial, Egypt