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NOT YET RECRUITING
NCT07539103

VIRal Pulmonary Infections in Older AGE

Sponsor: Gérond'if

View on ClinicalTrials.gov

Summary

Severe acute respiratory infections (SARIs) represent one of the leading causes of hospitalization and mortality worldwide. These infections are associated with substantial in-hospital mortality and often constitute a turning point in the medium-term prognosis of older patients and those with comorbid conditions. SARIs are most frequently of viral origin, involving well-known pathogens such as Orthomyxoviridae (influenza A and B viruses), Pneumoviridae \[(respiratory syncytial virus (RSV), human metapneumovirus (hMPV)\], Paramyxoviridae \[parainfluenza viruses (PIV)\], adenoviruses, or rhinoviruses, as well as emerging viruses such as pandemic influenza strains and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic. Age-related immune decline (immunosenescence) increases the risk of severe forms and related respiratory or cardiovascular complications. However, the prevalence and burden of the different viral etiologies of Severe acute respiratory infections (SARIs) in older adults remain limited and insufficiently characterized. The primary objective is to determine the proportion of viral respiratory infections attributable to polymerase chain reaction (PCR)-confirmed pathogen agents among hospitalized older subjects (≥60 years old).

Key Details

Gender

All

Age Range

60 Years - Any

Study Type

OBSERVATIONAL

Enrollment

5900

Start Date

2026-06-01

Completion Date

2028-09-30

Last Updated

2026-04-20

Healthy Volunteers

No

Locations (20)

CHU Bordeaux

Pessac, Bordeaux, France

CHU Amiens Picardie

Amiens, France

Centre Hospitalier Départemental Vendée_La Roche sur Yon

La Roche-sur-Yon, France

CHU Nimes

Nîmes, France

Hôpital St Antoine

Paris, France

Hôpital Broca - APHP

Paris, France

Hôpital Avicenne APHP

Bobigny, Île-de-France Region, France

Hôpital Ambroise Paré-APHP

Boulogne-Billancourt, Île-de-France Region, France

Hôpital Henri Mondor APHP

Créteil, Île-de-France Region, France

Hôpital Corentin Celton APHP, Gérontologie 1

Issy-les-Moulineaux, Île-de-France Region, France

Hôpital Corentin Celton APHP, Gérontologie 2

Issy-les-Moulineaux, Île-de-France Region, France

Hôpital Charles Foix APHP

Ivry-sur-Seine, Île-de-France Region, France

CH de Versailles

Le Chesnay, Île-de-France Region, France

Hôpital Emile Roux APHP

Limeil-Brévannes, Île-de-France Region, France

HEGP

Paris, Île-de-France Region, France

Hôpital Bretonneau APHP

Paris, Île-de-France Region, France

Hôpital Sainte Périne

Paris, Île-de-France Region, France

Hôpital Lariboisière - APHP

Paris, Île-de-France Region, France

Hôpital Bichat-APHP

Paris, Île-de-France Region, France

Hôpital Paul Brousse APHP

Villejuif, Île-de-France Region, France