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VIRal Pulmonary Infections in Older AGE
Sponsor: Gérond'if
Summary
Severe acute respiratory infections (SARIs) represent one of the leading causes of hospitalization and mortality worldwide. These infections are associated with substantial in-hospital mortality and often constitute a turning point in the medium-term prognosis of older patients and those with comorbid conditions. SARIs are most frequently of viral origin, involving well-known pathogens such as Orthomyxoviridae (influenza A and B viruses), Pneumoviridae \[(respiratory syncytial virus (RSV), human metapneumovirus (hMPV)\], Paramyxoviridae \[parainfluenza viruses (PIV)\], adenoviruses, or rhinoviruses, as well as emerging viruses such as pandemic influenza strains and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic. Age-related immune decline (immunosenescence) increases the risk of severe forms and related respiratory or cardiovascular complications. However, the prevalence and burden of the different viral etiologies of Severe acute respiratory infections (SARIs) in older adults remain limited and insufficiently characterized. The primary objective is to determine the proportion of viral respiratory infections attributable to polymerase chain reaction (PCR)-confirmed pathogen agents among hospitalized older subjects (≥60 years old).
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
OBSERVATIONAL
Enrollment
5900
Start Date
2026-06-01
Completion Date
2028-09-30
Last Updated
2026-04-20
Healthy Volunteers
No
Conditions
Locations (20)
CHU Bordeaux
Pessac, Bordeaux, France
CHU Amiens Picardie
Amiens, France
Centre Hospitalier Départemental Vendée_La Roche sur Yon
La Roche-sur-Yon, France
CHU Nimes
Nîmes, France
Hôpital St Antoine
Paris, France
Hôpital Broca - APHP
Paris, France
Hôpital Avicenne APHP
Bobigny, Île-de-France Region, France
Hôpital Ambroise Paré-APHP
Boulogne-Billancourt, Île-de-France Region, France
Hôpital Henri Mondor APHP
Créteil, Île-de-France Region, France
Hôpital Corentin Celton APHP, Gérontologie 1
Issy-les-Moulineaux, Île-de-France Region, France
Hôpital Corentin Celton APHP, Gérontologie 2
Issy-les-Moulineaux, Île-de-France Region, France
Hôpital Charles Foix APHP
Ivry-sur-Seine, Île-de-France Region, France
CH de Versailles
Le Chesnay, Île-de-France Region, France
Hôpital Emile Roux APHP
Limeil-Brévannes, Île-de-France Region, France
HEGP
Paris, Île-de-France Region, France
Hôpital Bretonneau APHP
Paris, Île-de-France Region, France
Hôpital Sainte Périne
Paris, Île-de-France Region, France
Hôpital Lariboisière - APHP
Paris, Île-de-France Region, France
Hôpital Bichat-APHP
Paris, Île-de-France Region, France
Hôpital Paul Brousse APHP
Villejuif, Île-de-France Region, France