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Effect of Rosmarinus Officinalis Extract on Oxidative Stress and Inflammatory Biomarkers in Patients With Type 2 Diabetes (T2DM)
Sponsor: Universidad Autonoma de Zacatecas
Summary
This randomized, placebo-controlled clinical trial evaluates the effects of a methanolic extract of Rosmarinus officinalis (rosemary) in patients with type 2 diabetes mellitus. Participants are randomly assigned to receive either methanolic rosemary extract or placebo in addition to their usual treatment and are followed for six months. A data cut-off at Month 3 is used for the analysis of metabolic, oxidative stress, and cytogenetic outcomes, while selected inflammatory and cardiovascular biomarkers continue to be assessed through Month 6. The study investigates the potential complementary effects of methanolic rosemary extract on metabolic control, oxidative stress, inflammation, genomic stability, and cardiovascular-related biomarkers in patients with type 2 diabetes mellitus.
Official title: Randomized Controlled Trial Evaluating the Effect of Rosmarinus Officinalis Extract on Metabolic, Hepatic, Renal, Inflammatory, and Oxidative Stress Biomarkers in Patients With Type 2 Diabetes.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-09-20
Completion Date
2027-01
Last Updated
2026-08-26
Healthy Volunteers
No
Interventions
Placebo
Inactive substance with no therapeutic effect.
Rosmarinus officinalis extract
Methanolic extract of Rosmarinus officinalis administered orally for 12 weeks
Locations (1)
ISSSTE (Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado)
Zacatecas City, Zacatecas, Mexico