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Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Summary
This is a pilot clinical trial to evaluate the feasibility and outcome of autologous transplantation of immature testicular tissue cryopreserved during childhood as a method of fertility preservation for prepubertal boys in case of gonadotoxic therapies. Freezing of immature testicular tissue is performed since the early 2000s and a number of our patients have now reached reproductive age. In case of childwish and azoospermia in adulthood, surgical sperm retrieval is planned and if unsucessful transplantation of the patient's own cryopreserved tissue will be performed during the same surgical intervention as a fertility restoration method.
Official title: Fertility Restoration With Autotransplantation of Cryopreserved Immature Testicular Tissue (ITT) Restaurer la fertilité à Partir de Tissu Testiculaire Immature (TTI) cryopréservé Par Auto-transplantation du Tissu
Key Details
Gender
MALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-11-19
Completion Date
2037-11
Last Updated
2026-04-21
Healthy Volunteers
No
Interventions
autologous transplantation of cryopreserved testicular tissue
Avascular autologous transplantation of frozen-thawed immature testicular tissue pieces will be performed in azoospermic adult patients during a surgical sperm retrieval procedure if no sperm is found peroperatively.
Locations (1)
Cliniques universitaires Saint-Luc, Université catholique de Louvain
Brussels, Belgium