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Verification of Range Accuracy and Correlation With Clinical Toxicity Using Offline PET/CT for Hypofractionated Proton Radiotherapy in Breast Cancer
Sponsor: Ruijin Hospital
Summary
This is a single-arm, single-center, prospective observational study. It uses offline PET/CT to verify and quantify the range accuracy of hypofractionated proton radiotherapy for postoperative breast cancer. The correlation between range error and clinical toxicities (radiation pneumonitis, rib fracture) will be analyzed. A PET signal-proton range correlation model will be established using Monte Carlo simulation to provide evidence for optimizing proton therapy planning.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2026-04-16
Completion Date
2028-08-31
Last Updated
2026-04-21
Healthy Volunteers
No
Conditions
Interventions
Offline PET/CT scanning
Offline PET/CT scan performed after proton therapy to verify range accuracy; no therapeutic intervention