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Low Versus High Dose OnabotulinumtoxinA for Chronic Anal Fissure
Sponsor: Tanta University
Summary
The goal of this clinical trial is to evaluate the efficacy of botulinum toxin injection in treatment of patients with chronic anal fissures comparing between two doses of botulinum toxin injection focusing on healing rate, fissure pain, incontinence and return to daily activity. patients will be divided into two groups group A) will receive 50IU from Botulinium toxin type A in the form of two injections at 3 o'clock and 9 o'clock without any anasthesia. While group B) will receive low dose injection in the form of 20IU by the same technique.
Official title: Low Versus High Dose OnabotulinumtoxinA for Chronic Anal Fissure: A Randomized Clinical Trial With 1-Year Follow-up
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2023-08-01
Completion Date
2026-08-30
Last Updated
2026-09-03
Healthy Volunteers
No
Conditions
Interventions
injection of Botulinum type A
injection of low dose 20 IU of Botoulinum toxin type A to arm 1 and high dose 50 IU to arm 2
Locations (1)
Faculty of Medicine Tanta University
Tanta, Egypt