Clinical Research Directory

Inclusion Criteria: * Age \> 21 * Stage II POP of anterior vaginal wall (Ba ≥ -1) * Symptomatic bulge symptoms * Positive response to PFDI-20 question 3: Do you usually have a bulge or something falling out that you can see or feel in the vaginal area? * AND any degree of bother. Providing any answer other than "not at all" to "how much does this bother you" * Abstinent, on contraception, or postmenopausal at time of injection * Must read or understand English Exclusion Criteria: * Concurrent apical or posterior prolapse \> stage 1 * Prior pelvic radiation * Previous vaginal reconstructive surgery (Except total vaginal hysterectomy or sling) * History of chronic vaginal infections (ex. Sexually transmitted infection or bacterial vaginosis) * Prior vaginal laser treatment \< 6 months * Planned vaginal laser/topical treatment * History of hypertrophic reaction to vicryl (polyglactin-910) * Allergy to Sculptra aesthetic or any components of Sculptra (PLLA, carboxymethylcellulose, non-pyrogenic mannitol) * Allergy to silicone * Premenopausal without contraception or abstinence during treatment phase * Currently breastfeeding * Connective tissue disorder * Uncontrolled diabetes (defined as HbA1c \> 8) * Does not read or understand English * Inability to provide informed consent * Physical limitations that would prevent subjects from performing the required pelvic wand massage sessions after each injection, such as significant arthritis or other mobility limitations. * Prescription anticoagulation therapy that cannot be safely discontinued (Aspirin and anti-platelet therapies would be considered acceptable) * Current use of other treatments for prolapse, such as pessary, in subjects who are unwilling to discontinue these treatments during the study period. * Planning to start pelvic floor physical therapy during the study * Undergoing physical therapy and not willing to stop internal therapy for 2 weeks after an injection or biopsy