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Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
Sponsor: Icahn School of Medicine at Mount Sinai
Summary
This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will effect pain control. 1. Does Suzetrigine given pre-operatively decrease the total opioid consumed after total knee replacement surgery? 2. Dose Suzetrigine given pre-operatively decrease the visual analog pain scale pain scores after total knee replacement surgery? Study participants will be randomly assigned to receive either Suzetrigine medication or placebo medication.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
235
Start Date
2026-04
Completion Date
2027-02-23
Last Updated
2026-04-23
Healthy Volunteers
No
Interventions
Suzetrigine
Suzetrigine is a new pain medication that works by inhibiting sodium channels (NAV 1.8) on pain nerves in the peripheral nervous system. By inhibiting this sodium channel on peripheral nerves it blocks pain signals from reaching the spinal cord and brain, decreasing pain.
Placebo
Matching placebo
Locations (1)
Mount Sinai West
New York, New York, United States