Clinical Research Directory

Inclusion Criteria: * Male and female subjects; * Age between 18 and 50 years; * Periodontally healthy subjects; * Patients with no history of orthodontic treatment; * Patients without gingival hypertrophy or hyperplasia. Exclusion Criteria: * Age \< 18 or \> 50 years; * Patients diagnosed with Stage I-IV periodontitis; * Patients currently undergoing orthodontic treatment; * Patients with severe dental crowding in the second sextant; * Patients taking medications associated with gingival hypertrophy or -hyperplasia; * Patients unwilling to provide informed consent; * Patients with fixed or removable prostheses in the second sextant; * Patients with a history of surgical procedures in the second sextant; * Patients with uncontrolled diabetes or neuropsychiatric disorders; * Patients with infectious diseases; * Pregnant or breastfeeding women, or those with suspected pregnancy; * Patients taking bisphosphonates; * Oncologic patients and those undergoing head and neck radiotherapy or receiving chemotherapy; * Patients with alcohol or drug abuse.