Clinical Research Directory
Browse clinical research sites, groups, and studies.
Acute Effects of Creatine and L-Arginine Co-Supplementation on Anaerobic and Cognitive Performance in Recreationally Active Males
Sponsor: Inonu University
Summary
This randomized, double-blind, four-period crossover trial investigates the acute effects of creatine monohydrate, L-arginine, and their combined administration on anaerobic performance, jump performance, and cognitive reaction time in recreationally active adult males. Eighteen healthy male participants complete four experimental conditions in randomized order: placebo, creatine, L-arginine, and creatine plus L-arginine, with at least 72 hours between sessions. Sixty minutes after supplementation, participants perform the Stroop Color-Word Test, countermovement jump test, and Running-Based Anaerobic Sprint Test. Primary outcomes include peak power, average power, countermovement jump height, and incongruent Stroop reaction time. The study aims to determine whether acute co-supplementation produces greater ergogenic and cognitive benefits than either supplement alone or placebo.
Official title: Acute Effects of Creatine and L-Arginine Co-Supplementation on Anaerobic Power, Jump Performance, and Cognitive Reaction Time in Recreationally Active Males: A Randomized Crossover Trial
Key Details
Gender
MALE
Age Range
18 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2025-04-01
Completion Date
2025-05-16
Last Updated
2026-04-23
Healthy Volunteers
Yes
Interventions
Creatine Monohydrate
Acute oral creatine monohydrate supplementation at 0.3 g/kg body mass.
L-Arginine
Acute oral L-arginine supplementation at a dose of 6 g.
Placebo
Placebo beverage containing 6 g sucrose dissolved in 250 mL of water.
Locations (1)
Inonu University, Faculty of Sport Sciences
Malatya, Malatya, Turkey (Türkiye)